The analgesic potency of peripherally applied opioids is strongly increased in inflamed tissue. In this project we investigate how the function of the µ-opioid receptor is modulated by changes in pH as observed in the pathological state of inflammation. Following a multidisciplinary approach, we combine methods from molecular and cellular biology with molecular simulations to elucidate the mechanisms underlying observaations from behavioral experiments. Identifying disease-specific regulatory mechanisms will help to design novel opioids with reduced side effects.
Group members involved: Christoph Stein, Johanna Meyer, Giovanna Del Vecchio, Viola Seitz, Fatih Yergöz